Twentyone Hotel

Via Cola Di Rienzo 23, Vaticano Prati, Rome, Italy - Halfway between Vatican
4.0 1904 reviews

Featuring a restaurant and a barber shop, the 4-star Twentyone Hotel Rome lies only 9 minutes' walk from the large urban square "Piazza del Popolo". Featuring 88 rooms with views of the sea, this Rome hotel is in proximity to the 17th-century Sant'Agnese in Agone Baroque Church.

Location

Tribunale Ordinario di Roma Courthouse is 0.3 miles from the hotel, and Basilica of St. Mary of the Angels and the Martyrs is 1.5 miles from it. The Twentyone Rome is about 5 minutes' stroll from San Gioacchino ai Prati di Castello Cardinal Titular Church and only steps away from Lepanto subway station. A family vacation to Rome will become more exciting if you visit the ancient Roman Circus Maximus lying 1.9 miles from this property. The Rome hotel is located 13 miles from Ciampino airport and a few moments from Cicerone/Plinio bus stop.

Rooms

The rooms at Twentyone Hotel have individual climate control and a central heating. Some of them comprise a balcony and a sitting area, appointed with a study desk. Also, there is a private safe, a mini fridge bar and coffee/tea making facilities provided. Bathrooms include a spa bathtub and a sink, along with comforts such as dressing gowns and slippers.

Food & Drinks

The Twentyone is right around the corner from Route 66 and offers a broad selection of meals.

Why choose Twentyone Hotel Rome

Select room
  • Private terrace in deluxe rooms

  • Jacuzzi available in junior suites

  • Bistro 21 offers Mediterranean cuisine

  • Strategic location near Vatican

Main amenities

  • Wi-Fi

  • 24-hour services

  • Express check-in/ -out

  • Fitness/Gym

  • On-site Dining

  • No Smoking

  • Child-friendly

  • Wheelchair access

  • Breakfast

  • Air conditioning

  • No pets allowed

General
  • Wi-Fi
  • 24-hour services
  • Express check-in/ -out
  • Fitness/Gym
  • On-site Dining
  • No Smoking
  • Child-friendly
  • Wheelchair access
  • Breakfast
  • Air conditioning
  • No pets allowed
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Internet

  • Wi-Fi

Parking options

  • Parking

Shuttle

  • Paid airport shuttle

Activities

  • Fitness centre

Property services

  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • Security
  • Luggage storage
  • Barber shop
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Tours/Ticket assistance
  • Welcome drink

Dining options

  • In-room breakfast
  • Restaurant
  • Snack bar
  • Bar/ Lounge area
  • Packed lunches
  • Special diet menus

Business facilities

  • Fax/Photocopying

For kids

  • Cots
  • Children's buffet

Recreation

  • Garden area
  • Leisure/ TV room

For disabled guests

  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Toilet for disabled
  • Bathroom for disabled

In the rooms

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Sitting area
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Ironing facilities

In the bathroom

  • Free toiletries
  • Sink

Devices

  • Flat-screen TV
  • AM/FM alarm clock

Design

  • Carpeted floor

General facilities

  • Non-smoking rooms
  • Allergy-free rooms
  • Lift
  • Coffee shop
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers
  • Key card access

Pets

  • No pets allowed

Important information

Check-in:
from 15:00 until 23:59
Check-out:
from 07:00 until 11:00
License number058091-ALB-00313,IT058091A1GZ5MCI9I
  • Children and extra beds
  • There are no cribs provided in a room.

Enter dates to see availability

From USD 82 per night
Check-in 20 Mar 2026
Check-out 21 Mar 2026
Guests 2 guests

Adults:

2

Children:

0

Rooms

Photos of Twentyone Hotel Rome

Location of Twentyone Hotel Rome

Via Cola Di Rienzo 23, Vaticano Prati, Rome, Italy

 -  Halfway between Vatican
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    100% Verified Reviews
    Enter dates to see availability
    From USD 82 per night
    Check-in 20 Mar 2026
    Check-out 21 Mar 2026
    Guests 2 guests

    Adults:

    2

    Children:

    0
    Check-in & out
    20 Mar 2026
    21 Mar 2026
    Guests
    2 guests
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    Twentyone Hotel
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    Details:

    Via Cola Di Rienzo 23, Rome, Italy

    Important information
    Twentyone Hotel
    Check-in:
    from 15:00 until 23:59
    Check-out:
    from 07:00 until 11:00
    License number058091-ALB-00313,IT058091A1GZ5MCI9I
    • Children and extra beds
    • There are no cribs provided in a room.