Twentyone Hotel

Via Cola Di Rienzo 23, Vaticano Prati, Rome, Italy - Halfway between Vatican
4.0 1904 reviews

Providing 88 rooms, the 4-star Twentyone Hotel Rome is nestled approximately 5 minutes' walk from Tiber. Guests are offered with a charging station for electric vehicles for EUR 35 per day on site.

Location

Nestled 1.5 miles from Basilica of St. Mary of the Angels and the Martyrs, this Rome hotel is 1.3 miles from the ancient open-air Theatre of Marcellus. The aqueduct-fed rococo Trevi Fountain is also located about 25 minutes by foot from the Twentyone Rome. The hotel is an ideal starting point for visiting the large urban square "Piazza del Popolo", located 0.5 miles away. This property is located a few moments from Lepanto subway station and a 31-minute drive will be enough to get to Ciampino airport.

Rooms

The rooms at Twentyone Hotel include air conditioning. Some of them comprise a balcony and a sitting area, furnished with a study desk. In-room entertainment includes a flat-screen TV with satellite channels, the rooms also have a mini fridge bar and coffee/tea making facilities for self-catering. Bathroom amenities include a bidet, a separate toilet, and a shower, as well as comforts such as hairdryers and towels. These rooms offer views of the sea.

Food & Drinks

Dining options also include Le Sicilianedde, located fairly close to the Twentyone.

Why choose Twentyone Hotel Rome

Select room
  • Private terrace in deluxe rooms

  • Jacuzzi available in junior suites

  • Bistro 21 offers Mediterranean cuisine

  • Strategic location near Vatican

Main amenities

  • Wi-Fi

  • 24-hour services

  • Express check-in/ -out

  • Fitness/Gym

  • On-site Dining

  • No Smoking

  • Child-friendly

  • Wheelchair access

  • Breakfast

  • Air conditioning

  • No pets allowed

General
  • Wi-Fi
  • 24-hour services
  • Express check-in/ -out
  • Fitness/Gym
  • On-site Dining
  • No Smoking
  • Child-friendly
  • Wheelchair access
  • Breakfast
  • Air conditioning
  • No pets allowed
1/30

Internet

  • Wi-Fi

Parking options

  • Parking

Shuttle

  • Paid airport shuttle

Activities

  • Fitness centre

Property services

  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • Security
  • Luggage storage
  • Barber shop
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Tours/Ticket assistance
  • Welcome drink

Dining options

  • In-room breakfast
  • Restaurant
  • Snack bar
  • Bar/ Lounge area
  • Packed lunches
  • Special diet menus

Business facilities

  • Fax/Photocopying

For kids

  • Cots
  • Children's buffet

Recreation

  • Garden area
  • Leisure/ TV room

For disabled guests

  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Toilet for disabled
  • Bathroom for disabled

In the rooms

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Sitting area
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Ironing facilities

In the bathroom

  • Free toiletries
  • Sink

Devices

  • Flat-screen TV
  • AM/FM alarm clock

Design

  • Carpeted floor

General facilities

  • Non-smoking rooms
  • Allergy-free rooms
  • Lift
  • Coffee shop
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers
  • Key card access

Pets

  • No pets allowed

Important information

Check-in:
from 15:00 until 23:59
Check-out:
from 07:00 until 11:00
License number058091-ALB-00313,IT058091A1GZ5MCI9I
  • Children and extra beds
  • There are no cribs provided in a room.

Enter dates to see availability

From USD 82 per night
Check-in 8 May 2026
Check-out 9 May 2026
Guests 2 guests

Adults:

2

Children:

0
All rates verified
How we verified prices Our team regularly checks prices to make sure you see the lowest available rates. We compare them with hotel prices and other providers. If discounts or promotions appear, prices on our site are updated accordingly.

Rooms

Photos of Twentyone Hotel Rome

Location of Twentyone Hotel Rome

Via Cola Di Rienzo 23, Vaticano Prati, Rome, Italy

 -  Halfway between Vatican
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    100% Verified Reviews
    Enter dates to see availability
    From USD 82 per night
    Check-in 8 May 2026
    Check-out 9 May 2026
    Guests 2 guests

    Adults:

    2

    Children:

    0
    All rates verified
    How we verified prices Our team regularly checks prices to make sure you see the lowest available rates. We compare them with hotel prices and other providers. If discounts or promotions appear, prices on our site are updated accordingly.
    Check-in & out
    8 May 2026
    9 May 2026
    Guests
    2 guests
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    Important information
    Twentyone Hotel
    Check-in:
    from 15:00 until 23:59
    Check-out:
    from 07:00 until 11:00
    License number058091-ALB-00313,IT058091A1GZ5MCI9I
    • Children and extra beds
    • There are no cribs provided in a room.